The giant suburb of Chatsworth was developed in the mid-1960s - a creation of the apartheid policy of the Government in 1960s to house over 800 000 working class South African born Indians who had been displaced in terms of the Group Areas Act. A single State Health care facility, R. K. Khan Hospital, served the huge Indian population. In a five-year period in the 1980s, this hospital treated over 6500 patients suffering from cancer. With the progression of time, a large proportion of these patients would have been termed incurable and/or terminally ill and sent home to fend for themselves, with or without family support. There were no Hospices in Chatsworth to provide the specialized palliative care and medicine management which such patients required.

In 1991, a group of concerned persons came together with the express intention of establishing a hospice that could serve the needs of cancer patients in Chatsworth. They comprised medical and administrative staff and senior nurses from R. K. Khan Hospital, together with community-conscious individuals from the community. Strong local community support saw the establishment of Chatsworth Regional Hospice Association in the same year, operating from two small rooms at the back of the R.K.Khan Hospital and serviced by senior nursing staff who commenced home-based care on a voluntary basis for patients during their off-duty times. The Hospice Association was formally launched at a public meeting in 1992, where it was resolved that services would be provided free of charge to cancer patients at all stages of the disease.

In 2006, the services of the Hospice were extended to HIV AIDS patients. In 2016, the HIV AIDS programme was integrated into the home-based care service. This service was discontinued when the funding was dicointinued. All services remain cost free to patients and their families.